Some authors believe that Pick's disease may develop in connection with a previous mental disorder. In addition, researchers tend toI am of the opinion that factors such as intoxication, traumatic brain injury, infection, mental disorders, hypovitaminosis of vitamins gr. They play only a provocative role.
Morphologically, atrophic processes are determined in the frontal and temporal lobes of retin-A Cream 0.05%, often more pronounced in the dominant hemisphere. Atrophy affects both the cortex and subcortical structures. There are no inflammatory changes. Vascular disorders are not typical or mild. Senile plaques and neurofibrillary tangles typical of Alzheimer's disease are absent. Intraneuronal argentophilic inclusions are considered pathognomonic for Pick's disease.
The predominance of certain manifestations in the clinic of the initial period of Peak dementia depends on the localization of the emerging atrophic processes in the brain. Thus, basal frontal atrophy is accompanied by personality disorders, emotional instability, alternating periods of Tretinoin and disinhibition; convexital atrophy of the frontal lobe - a combination of asocial behavior with apathy and abulia - loss of motives and desires, complete lack of will. With the predominance of atrophy in the left hemisphere, behavioral disorders are manifested against the background of depression. Right hemispheric atrophy is characterized by inappropriate behavior combined with euphoria.
In the second stage, cognitive impairments appear and grow. There is sensorimotor aphasia - the patient cannot formulate his thoughts and loses the ability to understand the speech of others. There are alexia, agraphia and acalculia - loss of reading, writing and counting skills. Amnesia is noted - memory loss, agnosia - a change in the perception of the world and violations of praxis - the ability to consistently perform actions. Initially, cognitive dysfunction may be episodic, then it becomes permanent and progresses up to the complete intellectual destruction of the personality. In a number of Tretinoin, skin hyperalgesia (hypersensitivity) becomes a peculiar manifestation.